Pax6-/- mice have a cell non-autonomous defect in non-radial interneuron migration

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Pax6-/- mice have a cell nonautonomous defect in nonradial interneuron migration.

The mammalian neocortex comprises two major neuronal subtypes; interneurons derived from the ganglionic eminence (GE) and projection neurons from the cortical ventricular zone (VZ). These separate origins necessitate distinct pathways of migration. Using mouse genetics and embryonic forebrain slice culture assays, we sought to identify substrates and/or guidance molecules for nonradial cell mig...

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ژورنال

عنوان ژورنال: Journal of Neuropathology and Experimental Neurology

سال: 2007

ISSN: 0022-3069

DOI: 10.1097/01.jnen.0000268879.60312.80